Seeing and sensing single G protein-coupled receptors by atomic force microscopy
نویسندگان
چکیده
منابع مشابه
Force sensing and mapping by atomic force microscopy
Over the past 15 years, advances in the ¢eld of atomic force microscopy (AFM) have broadened its use from a high-resolution imaging instrument to a device capable of detecting and quantifying single molecular forces between surfaces in nearnative conditions. This article reviews developments in the force sensing ¢eld and focuses particularly on research that has seen the AFM utilised to produce...
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G protein-coupled receptors and heterotrimeric G proteins can diffuse laterally in the plasma membrane such that one receptor can catalyze the activation (GDP/GTP exchange) of multiple G proteins. In some cases, these processes are fast enough to support molecular signal amplification, where a single receptor maintains the activation of multiple G proteins at steady-state. Amplification in cell...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2019
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2018.10.006